Gene

brdt

ID

ZDB-GENE-030131-5928

Name

bromodomain, testis-specific

Symbol

brdt Nomenclature History

Previous Names

fi25h02
si:dkeyp-85h7.3
wu:fi25h02 (1)

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Predicted to have lysine-acetylated histone binding activity. Predicted to be involved in histone displacement; male gamete generation; and regulation of RNA metabolic process. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in azoospermia; oligospermia; and spermatogenic failure 21. Orthologous to human BRDT (bromodomain testis associated).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7159282 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With brdt Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
spermatogenic failure 21	Alliance	?Spermatogenic failure 21	617644

Associated With brdt Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018359	Bromodomain, conserved site
Domain	IPR001487	Bromodomain
Domain	IPR027353	NET domain
Domain	IPR031354	Bromodomain protein 4, C-terminal
Domain	IPR043508	Brdt, bromodomain, repeat I
Domain	IPR043509	Brdt, bromodomain, repeat II
Family	IPR050935	Bromodomain-containing chromatin reader
Homologous_superfamily	IPR036427	Bromodomain-like superfamily
Homologous_superfamily	IPR038336	NET domain superfamily

Domain Details Per Protein

Protein	Length	Brdt, bromodomain, repeat I	Brdt, bromodomain, repeat II	Bromodomain	Bromodomain, conserved site	Bromodomain-containing chromatin reader	Bromodomain-like superfamily	Bromodomain protein 4, C-terminal	NET domain	NET domain superfamily
UniProtKB:A0A0R4IJ54 InterPro	979
UniProtKB:I3IS77 InterPro	1093

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	brdt-202 (1) Ensembl	Ensembl	4,819 nt	Select Tool
mRNA	brdt-203 (1) Ensembl	Ensembl	1,050 nt	Select Tool
mRNA	brdt-204 (1) Ensembl	Ensembl	4,691 nt	Select Tool
mRNA	brdt-205 (1) Ensembl	Ensembl	4,960 nt	Select Tool ZFIN BLAST
ncRNA	brdt-003 (1) Ensembl	Ensembl	782 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations